Best MLB Strikeout Pitcher Matchups — Wednesday, May 6, 2026
Top strikeout spot: Tyler Glasnow
Tyler Glasnow (LAD) is the best strikeout matchup on the board at 100, projected for about 7.2 K against HOU. He's missing bats at a 30% clip — strikeouts per batter faced — and HOU has been whiff-prone, going down 23% of the time. He's lined up for about 23 batters, so the volume's there for a big number.
The rest of the top of the board
- Will Warren (NYY) (63) — about 5.7 K vs TEX: a 27% K/BF arm into a lineup that whiffs 22% of the time.
- Michael Soroka (AZ) (63) — about 5.9 K vs PIT: a 24% K/BF arm into a lineup that whiffs 24% of the time.
- Paul Skenes (PIT) (61) — about 5.5 K vs AZ: a 28% K/BF arm into a lineup that whiffs 21% of the time.
- Cole Ragans (KC) (59) — about 5.2 K vs CLE: a 30% K/BF arm into a lineup that whiffs 20% of the time.
- Zack Wheeler (PHI) (57) — about 5.4 K vs ATH: a 28% K/BF arm into a lineup that whiffs 20% of the time.
Whiffiest lineups to attack today
- CIN is striking out 24% of the time in this spot — Colin Rea is the arm to exploit it (41).
- PIT is striking out 24% of the time in this spot — Michael Soroka is the arm to exploit it (63).
- STL is striking out 23% of the time in this spot — Brandon Sproat is the arm to exploit it (37).
- HOU is striking out 23% of the time in this spot — Tyler Glasnow is the arm to exploit it (100).
How it played out
The top 10 starts averaged 5.5 strikeouts. Top play Tyler Glasnow punched out 2. We grade every projection against the box score so you can see how the board held up.
How to read these strikeout matchups
Each starter's score (0–100) weighs his strikeout ability against every hitter in the lineup, hand by hand, then factors in how deep he tends to pitch and his command. Higher means more whiffs point his way. The exact weighting is our own — we project a strikeout count and grade every start against what actually happened.