| Jul 20, 2025 | Max Holloway | L · Decision - Unanimous R5 | UFC 318: Holloway vs. Poirier 3 | -14 |
| Jun 2, 2024 | Islam Makhachev | L · Submission R5 | UFC 302: Makhachev vs. Poirier | -15 |
| Mar 10, 2024 | Benoît Saint Denis | W · KO/TKO R2 | UFC 299: O'Malley vs. Vera 2 | +19 |
| Jul 30, 2023 | Justin Gaethje | L · KO/TKO R2 | UFC 291: Poirier vs. Gaethje 2 | -22 |
| Nov 13, 2022 | Michael Chandler | W · Submission R3 | UFC 281: Adesanya vs. Pereira | +13 |
| Dec 12, 2021 | Charles Oliveira | L · Submission R3 | UFC 269: Oliveira vs. Poirier | -22 |
| Jul 11, 2021 | Conor McGregor | W · TKO - Doctor's Stoppage R1 | UFC 264: Poirier vs. McGregor 3 | +15 |
| Jan 24, 2021 | Conor McGregor | W · KO/TKO R2 | UFC 257: Poirier vs. McGregor 2 | +17 |
| Jun 28, 2020 | Dan Hooker | W · Decision - Unanimous R5 | UFC Fight Night: Poirier vs. Hooker | +15 |
| Sep 7, 2019 | Khabib Nurmagomedov | L · Submission R3 | UFC 242: Khabib vs. Poirier | -18 |
| Apr 14, 2019 | Max Holloway | W · Decision - Unanimous R5 | UFC 236: Holloway vs. Poirier 2 | +19 |
| Jul 29, 2018 | Eddie Alvarez | W · KO/TKO R2 | UFC Fight Night: Alvarez vs. Poirier 2 | +18 |
| Apr 15, 2018 | Justin Gaethje | W · KO/TKO R4 | UFC Fight Night: Poirier vs. Gaethje | +14 |
| Nov 12, 2017 | Anthony Pettis | W · KO/TKO R3 | UFC Fight Night: Poirier vs. Pettis | +13 |
| May 14, 2017 | Eddie Alvarez | NC · No Contest R2 | UFC 211: Miocic vs. dos Santos 2 | – |
| Feb 12, 2017 | Jim Miller | W · Decision - Majority R3 | UFC 208: Holm vs. de Randamie | +13 |
| Sep 18, 2016 | Michael Johnson | L · KO/TKO R1 | UFC Fight Night: Poirier vs. Johnson | -55 |
| Jun 5, 2016 | King Green | W · KO/TKO R1 | UFC 199: Rockhold vs. Bisping 2 | +27 |
| Jan 2, 2016 | Joe Duffy | W · Decision - Unanimous R3 | UFC 195: Lawler vs. Condit | +32 |
| Jun 6, 2015 | Yancy Medeiros | W · KO/TKO R1 | UFC Fight Night: Boetsch vs. Henderson | +34 |
| Apr 4, 2015 | Diego Ferreira | W · KO/TKO R1 | UFC Fight Night: Mendes vs. Lamas | +38 |
