Best MLB Runs Matchups — Tuesday, July 21, 2026
Top runs spot: Elly De La Cruz
Elly De La Cruz (CIN) tops the board at 100, facing RHP Luis Castillo. The lefty is scoring at .155 R/PA against righties this year — and .194 over the last two weeks, a strong bat that turns into a run in about 14% of his trips. And Luis Castillo has been getting lit up by righties lately — .210 runs per batter faced. One catch: the bullpen behind him has been stingy to that side late. He's hitting in a spot worth about 4.7 trips, so the volume's there. He's just .000 in 3 career PA against Luis Castillo, but that's a tiny sample and the matchup says regression. It all sets up in a neutral park.
The rest of the top of the board
- James Wood (WSH) (100) vs RHP Michael Lorenzen: an elite bat at .171 into an arm stingy with runs against the same side (.086).
- Sam Antonacci (CWS) (95) vs RHP Kumar Rocker: a strong bat at .143 into an arm getting lit up by the same side (.667).
- Gabriel Moreno (AZ) (91) vs RHP Jack Perkins: a solid bat at .127 into an arm getting lit up by the same side (.167).
- Munetaka Murakami (CWS) (91) vs RHP Kumar Rocker: a strong bat at .145 into an arm getting lit up by the same side (.667).
- Geraldo Perdomo (AZ) (88) vs RHP Jack Perkins: a strong bat at .136 into an arm getting lit up by the same side (.286).
- Zach Neto (LAA) (82) vs LHP Matthew Liberatore: a strong bat at .132 into an arm stingy with runs against the same side (.000).
- Gleyber Torres (DET) (82) vs LHP David Peterson: an excellent bat at .157 into an arm stingy with runs against the same side (.063).
Platoon edges to target
- Elly De La Cruz (CIN) — lefty bat vs RHP, .155 against righties this year.
- James Wood (WSH) — lefty bat vs RHP, .221 against righties this year.
- Sam Antonacci (CWS) — lefty bat vs RHP, .178 against righties this year.
- Munetaka Murakami (CWS) — lefty bat vs RHP, .195 against righties this year.
- Geraldo Perdomo (AZ) — lefty bat vs RHP, .133 against righties this year.
How it played out
4 of the top 10 runs matchups landed at least one run. Top play Elly De La Cruz finished with 1 run. We post the result next to every projection so you can grade the board yourself — and so the model gets re-tuned against what actually happened.
How to read these runs matchups
Each score (0–100) starts with the hitter's runs scored per plate appearance against the hand he's facing — weighted toward the last two weeks, then the season, then a two-year baseline. Then it layers in the bullpen, his spot in the order, and park and weather. Higher means more of it points his way. It's context, not a lock — a great spot still goes 0-for-4 sometimes, and a tough one runs into one. The edge is in stacking the odds, and since we grade every board, you can see how often the top of the list delivers.